培美曲塞和多西他赛分别联合适形大分割放疗治疗局部晚期老年非小细胞肺癌的疗效比较

Comparison on the therapeutic effects of pemetrexed and docetaxel respectively combined with conformal hypofractionated radiation therapy for old patients with local advanced non-small cell lung cancer

目的比较培美曲塞和多西他赛分别联合同期适形大分割放疗治疗局部晚期老年非小细胞肺癌(NSCLC)的近期疗效和不良反应。方法根据治疗方式的不同,将57例老年NSCLC患者分为培美曲塞组和多西他赛组。培美曲塞组接受培美曲塞联合同期适形大分割放疗,多西他赛组接受多西他赛联合同期适形大分割放疗,评估2组近期疗效和不良反应。结果培美曲塞组总有效率和1年生存率均略高于多西他赛组;2组不良反应主要包括放射性肺炎、放射性食管炎和骨髓抑制,但2组比较,差异无统计学意义。结论培美曲塞和多西他赛分别联合同期适形大分割放疗治疗NSCLC疗效相当,且不良反应较少,老年患者可耐受。

Objective To compare the short-term therapeutic effects and adverse reactions of pemetrexed and docetaxel respectively combined with conformal hypofractionated radiation therapy at the same term for old patients with local advanced non-small cell lung cancer（NSCLC）.Methods According to different treatment methods,57 old patients with NSCLC were divided into pemetrexed group and docetaxel group.Pemetrexed group was treated with pemetrexed combined with conformal hypofractionated radiation therapy,while docetaxel group with docetaxel combined with conformal hypofractionated radiation therapy.The short-term therapeutic effects and adverse reactions of two groups were compared.Results The total effectiveness rate and one-year survival rate of pemetrexed group were slightly higher than those of docetaxel group.The adverse reactions of two groups mainly included radiation pneumonitis,radiation esophagitis and myelosuppression.But compared with the adverse reactions of two groups,the difference showed no statistical significance.Conclusion Pemetrexed and docetaxel respectively combined with conformal hypofractionated radiation therapy at the same term in the treatment of old patients with NSCLC have similar therapeutic effects,less adverse reactions,and can be tolerated by old patients.