白细胞单采术治疗高白细胞急性白血病26例临床观察

Clinical analysis of 26 patients with leukapheresis in the treatment of hyperleukocytic acute leukemia

目的探讨白细胞单采术治疗高白细胞急性白血病的疗效。方法回顾性分析本院收治的26例高白细胞急性白血病患者的临床资料,观察化疗前行白细胞单采术治疗的效果。结果 26例患者中,25例临床症状缓解,外周血白细胞数显著下降,有效率达96.1%。结论白细胞单采术能迅速降低患者外周血中白血病细胞数目,减少体内白血病细胞负荷,有效防止肿瘤溶解综合征的发生,是治疗高白细胞急性白血病的有效方法。

Objective To evaluate the efficacy of leukapheresis in the treatment of hyperleukocytic acute leukemia.Methods Twenty six patients,who were performed leukapheresis with COBE Spectra before chemotherapy were analyzed respectively.Results Among 26 cases,25 cases achieved remission in clinical features,and dramatic reduction of WBC counts with an overall response rate of 96.1%.Conclusion Leukapheresis could prevent tumor lysis syndrome through reduction of leukemia cells burdens.It is an effective method for hyperleukocytic acute leukemia.