阿托伐他汀对慢性心力衰竭患者血清脑钠肽水平及心功能的影响

Effect of atorvastatin on BNP and cardiac function in patients with chronic heart failure

目的探讨阿托伐他汀对慢性心力衰竭(CHF)患者血清脑钠肽(BNP)水平及心功能的影响。方法将95例CHF患者随机分为治疗组和对照组。对照组给予常规ACEI、地高辛等基础治疗;治疗组进一步随机分为A、B、C共3个组,均在对照组基础上分别加用不同剂量的阿托伐他汀。治疗前及治疗后6、12周检测所有患者的左心室射血分数(LVEF)和血浆BNP浓度。结果与对照组比较,治疗组BNP下降水平和LVEF上升水平均更为显著(P<0.05);治疗后6周,B、C组血浆BNP水平及LVEF均较A组显著降低(P<0.05),但B、C组血浆BNP水平及LVEF经比较无显著差异(P>0.05);治疗后12周,A、B、C组BNP水平及LVEF与同组治疗后第6周比较均无显著差异(P>0.05)。结论阿托伐他汀能明显降低CHF患者血浆BNP水平,改善LVEF,有利于CHF患者心功能的改善。

Objective To assess the effect of atorvastatin on BNP level and cardiac function in patients with chronic heart failure（CHF）.Methods Ninety-five patients with CHF were randomly divided into treatment group and control group.The control group was treated with routine application of ACEI and digoxin,while the treatment group was randomly divided into groups A,B and C,which were treated with different doses of atorvastatin on the basis of control group respectively.Left ventricular ejection fraction（LVEF） and plasma BNP concentrations were measured before treatment and 6 weeks,12 weeks after treatment.Results The BNP level and LVEF level in the treatment group showed significant differences with those in the control group（P〈0.05）.Six weeks after treatment,the plasma BNP level and LVEF in the groups B and C were significantly lower than those in group A.However,the BNP level and LVEF between groups B and C showed no significant difference（P〈0.05）.Twelve weeks after treatment,BNP level and LVEF in groups B and C showed no significant difference with what they were on the sixth week（P〈0.05）.Conclusion Atorvastatin can significantly decrease the level of plasma BNP and improve LVEF in patients with chronic heart failure,which can do benefit to the improvement of cardiac function.