宫颈病变物理治疗后应用壳聚糖抗菌膜的临床价值分析

Clinical value of chitosan antimicrobial coating for cervical lesions after physical therapy

目的观察宫颈病变物理治疗后应用壳聚糖抗菌膜的临床疗效。方法将接受激光治疗的单纯重度宫颈糜烂患者200例随机分为A、B组,每组100例;再将接受宫颈环形电切术(LEEP)或包括冷刀锥切(CKC)治疗的CIN患者100例随机分为C、D组,每组50例。A、C组患者术后接受壳聚糖宫颈抗菌膜辅助治疗。比较4组患者阴道排液量、排液时间、出血量、出血时间以及宫颈愈合情况。结果 A组阴道排液量和出血量均显著少于B组,阴道排液时间及出血时间均显著短于B组,治愈与显效率显著高于B组;C组阴道流血及排液持续时间显著短于D组,C、D组阴道出血量、排液量、创面愈合情况无显著差异。结论物理治疗后联合应用壳聚糖宫颈抗菌膜可减少创面渗出及出血,提高创面愈合率,减轻患者痛苦,提高生活质量。

Objective To observe the clinical effects of chitosan antimicrobial coating in the treatment of cervical lesions after physical therapy.Methods Two hundred patients with simple severe cervical erosion treated with laser were randomly divided into groups A and B,100 cases in each group.Another 100 patients with cervical intraepithelial neoplasia（CIN） treated with loop electrosurgical excision procedure（LEEP） or cold knife conization（CKC） were randomly divided into groups C and D,50 cases in each group.The patients in groups A and C after operation received the adjuvant therapy of chitosan antimicrobial coating.The amount and time of vaginal discharge,bleeding amount and time as well as conditions of cervical healing were compared in four groups.Results The amounts of vaginal discharge and bleeding in group A were both less than those in group B significantly,times of vaginal discharge and bleeding obviously shorter than group B,and cure and effectiveness rates conspicuously higher than group B,all differences had statistical significance.Vaginal bleeding and discharge time in group C were notably shorter than those in group D,and there were no significant differences between groups C and D regarding the vaginal bleeding amount,discharge amount and conditions of wound healing.Conclusion Application of chitosan antimicrobial coating after physical therapy can reduce wound exudation,enhance wound healing rate,alleviate patients＇ pain and improve the quality of life.