常规治疗联合自拟消渴降糖方治疗2型糖尿病的疗效分析

Analysis on the therapeutic effect of routine therapy combined with self-made thirsty-removing and glucose-decreasing formula for type 2 diabetes mellitus

目的探讨常规治疗联合自拟消渴降糖方治疗2型糖尿病(T2DM)的临床疗效及安全性。方法将86例T2DM患者随机分为2组,每组43例。2组患者均采用饮食控制及运动疗法,并积极治疗并发症,同时口服二甲双胍片。联合组在此基础上给予自拟消渴降糖方。比较2组患者治疗前后空腹血糖(FPG)、餐后2小时血糖(2 hPG)、糖化血红蛋白(HbAlc)及血液流变学指标的变化;通过填写糖尿病特异生存质量量表比较2组各维度评分的变化,并观察不良反应发生情况。结果治疗后,2组FPG、2 hPG水平均较治疗前显著降低,且联合组FPG、2 hPG水平降低幅度显著大于西药组;联合组治疗后全血黏度(高切、中切、低切)、血浆黏度及纤维蛋白原水平均较治疗前显著改善,而西药组治疗后全血黏度(高切、中切)及血浆黏度较治疗前显著改善,且联合组各血液流变学指标降低幅度显著大于西药组;治疗后联合组生理、心理精神及治疗维度改善幅度均显著大于西药组。2组不良反应均轻微。结论常规治疗联合自拟消渴降糖方可有效改善T2DM患者的血糖水平及血液流变学指标,提高生存质量,达到预期心理、生理共同治疗的目的,且安全性好。

Objective To explore the clinical effect and safety of routine therapy combined with self-made thirsty-removing and glucose-decreasing formula for type 2 diabetes mellitus （T2DM）.Methods Eighty-six patients with T2DM were randomly divided into two groups,43 cases in each group.The patients in both groups were given dietary control and kinesitherapy,and their complications were also positively treated.They received diformin tablets during the same period.Based on this treatment,the combined group was given self-made thirsty-removing and glucose -decreasing formula.The changes of fasting plasma glucose （FPG）,2 h postprandial glucose （2 hPG）,glycosylated hemoglobin （HbAlc）,hemorheological indexes and each composite score by filling in diabetes-specific quality of life scale in two groups were compared,and the incidence of adverse reactions was observed.Changes of all dimensions were compared through particular life quality scale.The incidence of negative effects was observed.Results After treatment,FPG and 2 hPG levels in both groups significantly decreased,and the decreased degrees of FPG and 2 hPG levels in combined group were bigger than those in western group markedly.After treatment,the whole blood viscosity （high-cut,middle-cut and low-cut）,plasma viscosity and fibrinogen level in combined group as well as the whole blood viscosity （high-cut and middle-cut） and plasma viscosity in western group all improved notably,and the decreased degree of each hemorheological index in combined group were significantly bigger than those in western group.After treatment,the improved degrees of physical,psychological,mental and treatment composite in combined group were all larger than in western group.The adverse reactions in two groups were mild.Conelusion Routine therapy combined with self-made thirsty-removing and glucose-decreasing formula can effectively ameliorate the level of blood glucose and hemorheological indexes in patients with T2DM,improve quality of life,achieve the expected physical and psychological aims,and has good safety.