高同型半胱氨酸血症与缺血性脑卒中的相关因素分析

Analysis of the relevant factors between hyperhomocysteinemia and ischemic stroke

目的分析高同型半胱氨酸血症(Hhcy)与缺血性脑卒中的相关危险因素。方法回顾性分析本院收治的256例缺血性脑卒中患者的临床资料,其中102例伴有Hhcy,154例不伴有Hhcy。分别采用单因素及多因素Logistic回归分析对性别、年龄、吸烟、饮酒、叶酸、维生素B12、总胆固醇(TC)、甘油三酯(TG)、高血压病及糖尿病等10个因素进行分析。结果单因素分析表明,性别、年龄、吸烟、饮酒、叶酸和维生素B12水平与Hhcy明显相关,而与TC与TG浓度、高血压和糖尿病无明显相关。多因素分析表明,性别、年龄、吸烟、叶酸和维生素B12水平是缺血性脑卒中患者Hhcy发生的危险因素。结论缺血性脑卒中患者Hhcy的发生是多因素共同作用的结果,其独立危险因素为男性、老龄、吸烟、叶酸和维生素B12水平的降低。

Objective To analyze the relevant risk factors between hyperhomocysteinemia （Hhcy） and ischemic stroke.Methods The clinical data of 256 patients with ischemic stroke was analyzed retrospectively,among whom 102 cases were accompanied by Hhcy,while 154 cases not by Hhcy.One-way analysis and multifactor logistic regression analysis were respectively applied to analyze 10 factors like gender,age,smoking,drinking,folic acid,vitamin B 12,cholesterol （TC）,triglyceride （TG）,hypertension and diabetes.Results One-way analysis revealed that gender,age,smoking,drinking and levels of folic acid and vitamin B12 were obviously related to Hhcy,but not related to TC and TG concentrations,hypertension and diabetes.Multifactor logistic regression analysis demonstrated that gender,age,smoking,and levels of folic acid and vitamin B12 were the risk factors to induce occurrence of Hhcy in patients with ischemic stroke.Conclusion The occurrence of Hhcy in patients with ischemic stroke is caused by integrated factors,and its independent risk factors include male,aging,smoking and decreased levels of folic acid and vitamin B12.