初治菌阳结核患者抗结核治疗疗效与烟草依赖程度的关系

Relevance between curative efficacy of initial patients with sputum positive pulmonary tuberculosis and tobacco dependence

目的探讨初治菌阳结核患者抗结核治疗与烟草依赖程度的相关性。方法初治菌阳性患者463例,以有吸烟史患者185例为观察对象,278例不吸烟为对照组,均采用2HRZE/4HR(H异烟肼;E利福平;Z吡嗪酰胺;2代表用药2个月,4代表用药4个月)方案治疗,观察2组治疗效果以及对烟草依赖程度的变化。结果观察组治疗后患者烟草依赖程度较治疗前显著减轻(P<0.05);给药2个月、6个月后,观察组痰菌转阴率显著低于对照组(P<0.01,P<0.001);观察组空洞闭合率与对照组相比差异有统计学意义(P<0.01)。结论随着抗结核治疗的进展,烟草依赖程度不断减轻;烟草依赖程度可不同程度影响初治菌阳性患者的治疗。

Objective To analyze the relevance between curative efficacy of initial patients with sputum positive pulmonary tuberculosis and tobacco dependence.Methods Four hundred and sixty-three patients of initially sputum positive pulmonary tuberculosis were included in this study.185 patients who all had smoking history were placed in observation group,and 278 patients in control group.All the patients finished a course of chemotherapy （2HRZE/4HR）.Treatment effect and the changes in the tobacco dependence were observed.Results The tobacco dependence of the observation group significantly decreased after treatment （P ＜ 0.05）.The sputum converted to smear-negative in the observation group was significantly lower than the control group after 2 and 6 months （P＜0.01,P＜0.001）.Cavities cure rate between the two groups showed a significant difference（P＜ 0.01）.Conclusion With the progress of the treatment,tobacco dependence of anti -tuberculosis patients continuously decreases.Tobacco dependence can affect the treatment at a different level.