女性不孕症患者性激素水平变化

Changes of sex hormone levels in female infertility patients

目的研究性激素水平变化与不孕症的关系,探讨性激素检测在不孕症的临床应用价值。方法 124例不孕症设为月经正常组(38例)、月经紊乱组(86例),42例已育健康妇女为对照组,比较各组性激素水平情况。结果月经紊乱组尿促卵泡素(FSH)、促黄体生成素(LH)、催乳素(PRL)、雌二醇(E2)、与月经正常组、对照组比较差异均有统计学意义(P<0.05),月经正常组与对照组比较性激素水平差异无统计学意义(P>0.05)。催乳素血症、垂体微腺瘤FSH、LH、PRL升高、E2降低,子宫卵巢功能异常LH、睾酮(T)升高,黄体功能异常LH升高,与对照组比较差异均有统计学意义(P<0.05)。结论检测不孕症患者性激素,有助于了解患者月经紊乱及不孕症的具体病因及严重程度。

Objective To study the changes of sex hormone levels and infertility,and to explore the clinical value of hormone testing in infertility.Methods One hundred and twenty-four infertility patients were divided into the menstrual normal group （n =38）,menstrual disorders group （n =86）,and healthy women （n =42）as a control group.Levels of sex hormones were compared between the three groups.Results FSH,LH,PRL,E2 of menstrual disorders group and menstrual normal group were compared with those of the control group.The difference were statistically significant （P ＜ 0.05）.Sex hormone levels of the menstrual normal group,compared with the control group,were not statistically different （P ＞ 0.05）.Hyperprolactinemia,pituitary adenoma FSH,LH,PRL rose,E2 decreased,uterine and ovarian dysfunction LH,T rose,the emergence of abnormal luteal LH increased compared with the control group,the difference being statistically different（P＜ 0.05）.Conclusion Detection of sex hormone levels in infertility patients helps understand patients with menstrual disorders and infertility etiology and severity.