吸入性糖皮质激素在小儿毛细支气管炎的临床应用及对肺功能影响

Clinical application of inhaled glucocorticosteroid in children with bronchiolitis and its influence for lung function

目的探讨吸入性糖皮质激素在小儿毛细支气管炎的临床应用及对肺功能的影响。方法将116例毛细支气管炎患儿随机分入对照组与观察组,2组患者均给予抗感染、祛痰等对症治疗,观察组同时给予布地奈德雾化吸入,疗程3月,比较2组临床疗效、症状体征消失时间及肺功能的改变。结果观察组治疗总有效率显著高于对照组(96.7%vs 71.4%,P<0.05);观察组喘憋、咳嗽、哮鸣音消失时间及住院时间均显著早于对照组(P<0.05);治疗后观察组潮气量、达峰时间比(tPTEF/tE)和达峰容积比(VPTEF/VE)显著优于对照组(P<0.05)。结论毛细支气管炎患儿吸入糖皮质激素可促进病情恢复,改善肺功能。

Objective To explore the clinical effect of inhaled glucocorticosteroid in children with bronchiolitis and its influence on lung function.Methods One hundred and sixteen children with bronchiolitis were randomly divided into control group and observation group.The two groups were both given routine treatment and the observation group given extra inhaled budesonide.The treatment course was 3 months.Clinical effect,the time of clinical symptoms and signs disappearance and lung function were compared between the two groups.Results The efficacy rate of the observation group was much higher than that of the control group （96.7％ vs 71.4％,P＜0.05）.The disappearance time of wheezes,cough,wheezing rale and hospitalization duration of the observation group was much earlier than those in control group （P ＜ 0.05）.Tidal volume,tPTEF/tE and VPTEF/VE in the observation group were superior to the control group （P＜0.05）.Conclusion Inhaled glucocorticosteroid for children with bronchiolitis promotes the disease recovery and improves lung function.