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子宫颈鳞状细胞癌中p16和CXCR4的表达及意义 被引量:3

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摘要 目的探讨p16、CXCR4蛋白在子宫颈鳞状细胞癌中的表达及其相互关系。方法采用免疫组化SABC法检测96例子宫颈鳞状细胞癌中p16和CXCR4的表达情况。结果96例子宫颈鳞状细胞癌中,p16和CXCR4的阳性率分别为75.0%和68.8%。p16表达与子宫颈鳞状细胞癌的分期有关,而CXCR4过表达与子宫颈鳞状细胞癌淋巴转移有关。结论子宫颈鳞状细胞癌的发生与p16、CXCR4过表达有关;检测p16和CXCR4的表达对于临床早期诊断子宫颈鳞状细胞癌具有较高的参考价值。
作者 王文普 孙红
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第8期914-915,918,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 河北省教育厅科学研究计划(2008139) 河北省卫生厅科学研究计划项目(08179)
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