系统性红斑狼疮并发无菌性股骨头坏死的相关因素研究

Risk factors of systemic lupus erythematosus patients with aseptic necrosis of the femoral head

目的探讨系统性红斑狼疮并发无菌性股骨头坏死的相关因素。方法选择本院收治的系统性红斑狼疮患者84例,分为并发无菌性股骨头坏死42例(观察组)和无并发无菌性股骨头坏死42例(对照组),分析系统性红斑狼疮并发无菌性股骨头坏死的相关因素。结果观察组血管炎、雷诺现象以及Acl阳性的发生率均明显高于对照组,差异有统计学意义(P<0.05);观察组中19例患者使用激素冲击治疗,而对照组仅有8例,差异有统计学意义(P<0.05)。结论以血管炎、雷诺现象为主要临床表现的系统性红斑狼疮患者,其脉管系统对激素敏感性增加,大剂量激素冲击治疗容易并发无菌性股骨头坏死。

Objective To study the risk factors of systemic lupus erythematosus with aseptic necrosis of the femoral head. Methods Eighty - four patients with systemic lupus erythematosus in our hospital were divided into two groups, including 42 patients with aseptic femoral head necrosis （observation group） and 42 cases of without aseptic femoral head necrosis in patients （control group）. Related factors concerning systemic lupus erythematosus with aseptic necrosis of the femoral head were analyzed. Results Occurrences of vasculitis, Raynaud＇s phenomenon, and the ACL- positive of the observation group were higher than those of the control group, the difference being statistically significant （P 〈 0.05）. In the observation group, 19 patients were applied with steroid pulse therapy, while in the control group, only eight cases, the difference between the two groups being statistically significant （P 〈 0.05）. Conclusion For patients with systemic lupus erythematosus vasculitis, Raynaud＇s phenomenon as the main clinical manifestations, its vascular system is more sensitive to the hormone. Largedose hormone therapy can easily lead to aseptic necrosis of the femoral head.