健脾解毒方结合卡培他滨片治疗晚期大肠癌临床研究

Combination of “Jianpi Jiedu Decoction”and Capecitabine for the Treatment of Advanced Colorectal Cancer

目的:观察健脾解毒方结合卡培他滨片治疗晚期大肠癌的临床疗效。方法:将60例大肠癌患者随机分为两组,各30例;对照组给予卡培他滨片治疗,治疗组给予健脾解毒方结合卡培他滨片治疗,21天为1个周期,共治疗2个周期。观察两组临床疗效、中医证候疗效、生存质量和不良反应发生情况。结果:两组临床疗效比较组间差异均无统计学意义(P>0.05);治疗后治疗组中医证候积分较治疗前明显降低(P<0.05),且治疗组低于对照组(P<0.05);两组中医证候疗效比较差异无统计学意义(P>0.05);两组疲倦等生存质量评分较治疗前明显降低(P<0.05),且治疗组低于对照组(P<0.05);治疗组骨髓抑制等不良反应发生率明显少于对照组(P<0.05)。结论:健脾解毒方有助于改善晚期大肠癌的临床证候,提高生存质量,降低不良反应。

Objective ： To observe the clinical efficacy of “ Jianpi Jiedu Decoction” combined with Capecitabine in treating advanced colorectal cancer. Methods ： Sixty cases with colorectal cancer were randomly divided into two groups ： control group in which 30 cases were treated by Capecitabine Tablet, and treatment group in which 30 cases were treated by “ Jianpi Jiedu Decoction” and Capecitabine Tablet. Twenty days as a course,and treated for 2 weeks. The clinical efficacy,TCM syndrome, quality of life and adverse reaction were observed. Results ： No statistical significance was found in clinical efficacy between the two groups （P 〉0. 05） ; after treatment,the TCM syndrome score in treatment group was decreased significantly （ P 〈0. 05 ）, and the TCM syndrome score in treatment group was lower than that of the controls （P 〈0. 05） ; no statistical significance was found in TCM syndrome between the two groups （ P 〉 0. 05 ） ; the QOL score in both of the groups were decreased markedly after treatment （ P〈0. 05 ）,and the QOL score in treatment group was lower than that of the controls （ P 〈 0. 05 ） ; the occurrence rate of adverse reaction in treatment group was lower than that of the controls （ P 〈0.05）. Conclusion ： “ Jianpi Jiedu Decoction” is effective to improve the clinical syndromes, improve the QOL and reduce the adverse reaction in patients with advanced colorectal cancer.