联合用药治疗艾滋病的新进展

Recent Advances of Study on Combined with Antiretroviral Therapy for AIDS

近年来,联合用药已成为临床治疗艾滋病的主要方法,其优势为:①多靶点抑制HIV的复制,延缓HIV感染的临床进展;②将HIV抗药性产生的几率降低到最低限度;③显著提高爱滋病患者的生活质量与存活率。但联合用药也有一些缺陷,如治疗费用高、不良反应多以及产生交叉抗药性等 其缺陷可能导致患者难以耐受长期治疗,甚至导致治疗失败。制定科学的联合用药方案,有机结合合理的补救治疗策略以及替代疗法,是克服其缺陷的主要手段。

In recent years, combined with antiretroviral therapy has become a main strategy in the treatment of AIDS. Its superiorities have: 1) maximizing suppression of HIV replication and delaying the process of HIV-infection; 2) preventing viral resistance; enhancing life quality of patients with HIV-infection and reducing mobility/mortlaily of AIDS significantly. It also, however, has several potential defects, such as high cost, more adverse reactions and cross-resistance, which may lead to patients to tolerate the long term treatment diffiecdtly, even resthing in treatment to fail. An ideal sohtion to this problem is intredueing combined antiretroviral therapy, supplemented by savage treatment and substitute reginten. In presem. the recent advences of study on combined amtiretmviral thempy for AIDS are reviewel.