奥扎格雷钠治疗急性脑梗死的疗效

Clinical observations on the therapeutic effect of sodium ozagrel in treatment of acute cerebral infarction

目的 :观察奥扎格雷钠对急性脑梗死的疗效。方法 :选择诊断明确的急性脑梗死患者 6 4例 ,随机分为 2组 ,治疗组 32例 ,奥扎格雷钠 80 m g溶于 2 5 0 ml生理盐水中 iv gtt,bid,2 wk为一疗程。对照组 32例 ,低分子右旋糖酐 5 0 0 ml,加丹参注射液 16 m l,iv gtt,qd,连用 14d。按临床神经功能缺损程度评分标准于治疗前后 14d进行疗效评判。结果 :治疗组总有效率和显效率与对照组有显著性差别 (P<0 .0 1) ,实验室检查各项指标也有显著性意义。结论 :奥扎格雷钠临床观察疗效满意 ,且无明显不良反应 。

AIM: To observe the curative effect in treatment of acute cerebral infarction with sodium ozagrel. METHODS: We selected 64 confirmed cases of acute cerebral infarction. The subjects were randomly divided into 2 groups: In the control group there were 32 cases who were treated with dextran 40 (Rheotran) 500 ml plus red sage root injection 16 ml iv gtt qd×14 d. In the trial group there were 32 cases who were treated with ozagrel 80 mg iv gtt bid×14 d. We judged the clinical nervous function and defect degree before and after 14 d treatment according to the nervous defect standard (NDS) to analyse the curative effect. RESULTS: There was an apparent difference in general effective rate and significantly effective rate between the trial group and the control group ( P <0 01), in all laboratory indexes there was also an apparent significance. CONCLUSION: The curative effect of ozagrel is satisfactory without any toxic and side effects. These results suggest that sodium ozagrel is an effective and safe medicine in the treatment of acute cerebral infarction.