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右美托咪定和咪达唑仑用于妇科手术患者镇静效果比较

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摘要 目的比较右美托咪定和咪达唑仑在腰-硬联合麻醉中的镇静效果。方法腰-硬联合麻醉下择期行妇科子宫全切术和(或)卵巢囊肿切除术患者80例,随机分为Y组和M组,各40例。分别于麻醉平面固定后静脉输注右美托咪定0.6μg/kg和咪达唑仑0.06 mg/kg,观察给药前(T0)、切皮前即给药后10 min(T1)、手术开始5 min(T2)、15 min(T3)、30 min(T4)、45 min(T5)、术毕(T6)、术后1 h(T7)的心率(HR)、平均动脉压(MAP)、脉搏血氧饱和度(SpO2)、Narcotrend趋势指数(Narcotrend Index,NI)、Ramsay镇静评分,比较2组患者的镇静效果和不良反应。结果 NI在T2~5P<0.05;Ramsay评分在T1~4,P<0.05;HR在T1~4差异有统计学意义,MAP在T1~3差异有统计学意义;呼吸抑制、嗜睡差异有统计学意义。结论 0.6μg/kg右美托咪定应用于腰-硬联合麻醉下妇科手术,镇静作用更好,不良反应更少,无呼吸抑制,安全可行。
作者 张慎波
出处 《河南外科学杂志》 2013年第4期70-72,共3页 Henan Journal of Surgery
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