摘要
本文采用文献资料法,对阿片肽及受体参与运动预适应(EP)心肌保护作用及其机制的研究现状进行分析与总结,认为阿片肽及受体参与了EP心肌保护过程,其机制包括EP早期时相(EPC)和晚期时相(DPC)均发挥重要效应,细胞信号转导通路可能为内源性阿片肽(EOP)释放,活化以蛋白激酶C(PKC)为主的蛋白激酶,从而调控效应分子,发挥心肌保护效应。EP的本质就是通过运动应激手段,诱导机体内源性保护机制,从而提高心肌耐受缺血缺氧的能力。
This dissertation analyzes and summarizes current situations of research on the action and mechanism of opioid peptides and receptors in（exercise preconditioning）EP myocardial protection through the method of documentation.It deems that the opioid peptides and receptors are involved in the process of EP myocardial protection,and the mechanism exerts its effects in the early preconditioning（EPC）and delayed preconditioning（DPC）of the EP.Cell signal transduction pathway may be released for endogenous opioid peptides（EOP）,activate protein kinase dominated by protein kinase C（PKC）,thereby regulating effect factors and exerting effects on myocardial protection.EP substantially induces the endogenous protection mechanism of organism by means of exercise stress,thus improving myocardial ischemia.
出处
《保健医学研究与实践》
2013年第3期88-91,共4页
Health Medicine Research and Practice
基金
安徽省高校省级自然科学研究项目"β-内啡肽对运动心肌缺血预适应作用机制的研究"(KJ2012Z326)
项目负责人:王强
关键词
阿片肽
心肌
运动预适应
Opioid peptide
Myocardium
Exercise preconditioning
