固体制剂工艺对药物晶型的影响

Effect of Manufacturing Processes of Solid Dosage Forms on Polymorphism of Drugs

综述了固体制剂加工生产各因素对药物晶型的影响。指出精制、粉碎 ,制粒、干燥和压片都可能引起药物晶型发生变化 。

Various factors in manufacturing processes of solid dosage forms such as recrystallization, grinding, granulating, drying and compressing which might affect polymorphism of drugs, resulted in the change of bioavailability and their therapeutic efficacy.