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VEGF-CmRNA在口腔鳞癌中的表达 被引量：2

EXPRESSION OF VEGF C mRNA IN ORAL SQUAMOUS CARCINOMAS
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摘要 目的 :探讨血管内皮生长因子 - C(VEGF- C) m RNA在正常口腔粘膜、白斑及鳞癌等组织中的表达。方法 :RT- PCR法检测 VEGF- C m RNA的表达。结果 :鳞癌组织 VEGF- C m RNA表达明显高于正常口腔粘膜及白斑 (P <0 .0 1) ;鳞癌表达与病理分级 (P <0 .0 1)、淋巴结转移 (P <0 .0 1)密切相关 ,与临床分期无关 (P >0 .0 5 )。结论 :VEGF- C对鳞癌的生长及转移有促进作用 ,有望作为检测淋巴管转移及判断预后的指标之一。 Objective:To investigate the expression of VEGF C mRNA in oral squamous carcinoma tissues Method:RT PCR was used to determine the VEGF C mRNA expression in 56 carcinomas tissues and 10 normal mucosa tissues and 10 tissue Results:The expression of VEGF C mRNA in cancers was significantly higher than that in normal and vitiligo tissues (P<0 01) The VEGF C mRNA expression was correlated with pathological grades (P<0 01),lymph node metastasis (P<0 01),but not with clinical grades (P>0 05) Conclusion:VEGF C promotes growth and metastasis of Oral squamous carcinoma VEGF C might be one of the predictors for metastasis and prognosis
作者 于大海 温玉明 欧子民 邝海 韦山良 蒙宁
机构地区 广西医科大学口腔医学院外科 华西医科大学口腔医学院外科
出处 《广西医科大学学报》 CAS 2000年第5期763-765,共3页 Journal of Guangxi Medical University
基金 广西青年科学基金!资助 (桂科青 9912 0 2 0 )
关键词 血管内皮生长因子-C 口腔鳞 TR-PCR MRNA Oral squamous carcinoma VEGF C RT PCR
分类号 R739.850.2 [医药卫生—肿瘤]
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参考文献14

  • 1JoukovV,PajusolaK,KaipainenA,etal.Anovelvascularendothelialgrowthfactor,VEGF-C,isaligandfortheFlt4(VEGFR-3)andKDR(VEGFR-2)receptortyrosinekinases.EMBO-J,1996,15(2):290-298.
  • 2KukkE,LymboussakiA,TairaS,etal.VEGF-CreceptorbindingandpatternofexpressionwithVEGFR-3suggestsaroleinlymphaticvasculardevelopment.Development,1996,122(12):3829-3837.
  • 3NicosiaRJ.Whatistheroleofvascularendothelialgrowthfactor-relatedmoleculesintumorangiogenesis.AmJPatho,1998,153(1):11-16.
  • 4SalvenP,LymboussakiA,HeikkilaP,etal.VascularendothelialgrowthfactorsVEGF-BandVEGF-Careexpressedinhumantumors.AmJPathol,1998,153(1):103-108.
  • 5JoukovV,PajusolaK,KaipainenA,etal.Anovelvascularendothelialgrowthfactor,VEGF-C,isaligandfortheFlt4(VEGFR-3)andKDR(VEGFR-2)receptortyrosinekinases.EMBOJ,1996,15(2):290-298.
  • 6JeltschM,KaipainenA,JoukovV,etal.HyperplasiaoflymphaticvesselsinVEGF-Ctransgenicmice.Science,1997,276(30):1423-1425.
  • 7YonemuraY,EndoY,FujitaH,etal.RoleofvascularendothelialgrowthfactorCexpressioninthedevelopmentoflymphnodemetastasisingastriccancer.ClinCancerRes,1999,5(7):1823-1829.
  • 8KurebayashiJ,OtsukiT,KunisueH,etal.Expressionofvascularendothelialgrowthfactor(VEGF)familymembersinbreastcancer.JpnJCancerRes,1999,90(9):977-981
  • 9CarterRL.Someaspectsofmetastaticprocess.JClinPathol,1982,35:104.
  • 10景纯,温玉明,王大章,王昌美.口腔颊、舌鳞癌癌周淋巴管形态学特征与颈淋巴结转移[J].华西口腔医学杂志,1995,13(2):130-134. 被引量：26

二级参考文献3

共引文献25

同被引文献14

  • 1景纯,温玉明,王大章,王昌美.口腔颊、舌鳞癌癌周淋巴管形态学特征与颈淋巴结转移[J].华西口腔医学杂志,1995,13(2):130-134. 被引量：26
  • 2Cao Y, Linden P, Farnebo J, Cao R, et al. Vascular endothelial growth factor C induces angiogenesis in vivo [J]. Proc Natl Acad Sci U S A, 1998, 95(24):14389-14394.
  • 3Hofmann M, Rudy W, Zoller M, et al. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumour cell line [J]. Cancer Res, 1991, 51:5292-5297.
  • 4Tsurusaki T, Kanda S, Sakai H, et al. Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis [J]. Br J Cancer, 1999, 80(1-2):309-313.
  • 5Lymboussaki A, Olofsson B, Eriksson U, et al. Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia [J]. Circ Res, 1999,85(11):992-999.
  • 6Roselle J, Eisma BS, Jeffrey D, et al. Vascular endothelial growth factor expression in head and neck squamous cell carcinoma [J]. Am J Surg, 1997, 174: 513-517.
  • 7Dray TG, Hardin NJ, Sofferman RA, et al. Angiogenesis as a prognostic marker in early head and neck cancer [J]. Ann Otol Rhiol Laryngol, 1995; 104:724-729.
  • 8Ari Ristim, Kirsi Narko, Berndt Enholm, et al. Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C [J]. J Biol Chem, 1998, 273:8413-8418.
  • 9Berger DP, Herbstritt L, Dengler WA, et al. Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies [J]. Ann Oncol, 1995, 6: 817-825.
  • 10Joukov V, Kumar V, Sorsa T, et al. A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities [J]. J Bio Chem, 1998, 273(12):6599-6602.

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广西医科大学学报
2000年 第5期

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