摘要
目的:研究氨基末端B型钠尿肽原(NT-proBNP)测定在心力衰竭(HF)诊治中的作用;方法:利用酶联免疫荧光法检测408例HF患者及50例正常对照NT-proBNP水平,并跟踪观察HF患者在治疗过程中NT-proBNP水平的变化;结果:408例HF患者血浆NT-proBNP测定值中位数为4 245 ng/L(1 535 ng/L^11 158 ng/L),明显高于非HF患者,差异有显著意义(P<0.001),且增高幅度与心功能不全严重程度有关,各分级间的差异有显著意义(P﹤0.05);治疗过程中随着患者病情好转,NT-proBNP水平有不同程度的下降;患者病情恶化则NT-proBNP水平进一步升高;结论:血浆NT-proBNP水平检测对HF患者初筛、早期诊断、不同程度患者评估、治疗及疗效监测具有重要临床价值。
Objective: To investigate the value of N- terminal Pro- brain natriuretic peptide (NT- proBNP) level in diagnosis and treatment of heart failure (HF). Methods: Enzyme -linked immunosorbent fluorescence as- say was used to determine the NT - proBNP levels in 408 patients with HF and 50 heath volunteers. The dynamic changes of NT - proBNP level in patients were followed during the treatment. Results: The median for NT - proB- NP in HF patients ( n = 408 ) was 4245 ng/L ( 1535 ng/L - 11158 ng/L), significantly higher than that from health volunteers (P 〈 0. 001 ). NT - proBNP levels were positively correlated with the severity of heart failure development ( P 〈 0.05 ). It decreased with ameliorated symptoms of HF after therapy and increased with deteriorated symptoms. Conclusion: Plasma NT- proBNP levels has important clinical value in initial screening, early diagnosis, assess- ment, treatment and monitoring of patients with varying degrees of heart failure.
出处
《中国卫生检验杂志》
北大核心
2013年第8期1927-1929,共3页
Chinese Journal of Health Laboratory Technology
关键词
氨基末端B型钠尿肽原
心力衰竭
诊断和治疗
N -terminal Pro -brain natriuretic peptide
Heart failure
Diagnosis and treatment