部分抗结核分枝杆菌药物的耐药机理研究进展

Advances in reseach on M y cobacterium tuberculosis drug resistance mechanism

结核病是危害严重的重大传染病之一,抗结核药物的应用在治疗结核病的过程中具有重要意义。然而抗结核药物治疗不当会引起耐多药和广泛耐药结核分枝杆菌的出现,导致结核病抬头。结核的耐药多与耐药基因突变有关,笔者总结了常见抗结核药物的耐药分子机制的研究进展,为耐药结核的诊断和治疗提供分子依据。

Tuberculosis was one of most serious infectious diseases that were harmful to human health.Antibiotics was effective treatment against this bacterium.But the emergency of multi-and extensively drug-resistant Mycobacterium tuberculosis（Mtb） were occurred frequently when the use of antibiotics was unproper.Drug-resistant phenotype was due to mutations in drug resistant related genes,this paper will state the progress in mechanism study of drug resistant Mtb,which will guide the diagnosis and treatment of drug resistant Mtb.