短肽营养制剂对老年大肠癌患者术前肠道准备的临床效果

The influence of preoperative bowel preparation with oligopeptide nutrition in elderly patients with colorectal cancer

[目的]观察肠内短肽营养剂百普素用于老年大肠癌手术前准备的临床效果,探讨其辅助手术前肠道准备代替传统肠道准备的可行性和效果,为老年大肠癌患者术前肠道准备提供科学方法。[方法]选择本院2007～2012年间收治的100例57岁以上的大肠癌患者,采用随机抽样法将患者分为2组,每组50例,实验组采用百普素作术前肠道准备,对照组采用传统的流质饮食、禁食补液、反复导泻方法进行肠道准备,比较2组肠道准备效果、术前3d及术后1、3、7d营养指标(血红蛋白、白蛋白、前白蛋白)及免疫指标、术后肠道功能恢复状况。[结果]实验组肠道准备效果明显优于对照组(P<0.05);术后第1、3、7天血红蛋白、白蛋白、前白蛋白及免疫指标均显著高于对照组(P<0.05);术后肛门排气时间与对照组相比差异无统计学意义(P>0.05)。[结论]老年大肠癌患者术前使用百普素辅助肠道效果满意,优于传统方法:能有效改善患者的营养状况,增强机体免疫功能,加快术后肠道功能恢复,具有临床推广价值。

[Objective]To explore the effects of peptisorb （a oligopeptide nutrition preparation） on bowel preparation in elderly patients （〉57 ages） who suffered colorectal cancer before undergoing surgery. [Methods]One hundred patients with colorectal cancer in our hospital during 2007~2012 were randomized into experimental group （50 cases） and control group （50 cases）. The experimental group received oli- gopeptide nutrition preparation orally and the other group received traditional cleaning enema. Then the scores of bowel preparation, nutritional status, preoperative immunization status and postoperative intesti- nal function were recored. [Results]The effect of experimental group was better than control group （P~ 0.05）. Moreover, the albumin level, lymphocytes, and the ratio of Cy）4＋/CD8＋ were higher compared with control group. Compared with control group, the intestinal function of experimental group restored faster and better. Furthermore, the incidence of adverse effect of experimental group was lower than that of con- trol group. [Conclusion]The effect of oral oligopeptide nutrition for bowel preparation is obvious superior to that of traditional cleaning enema in elderly patients with colorectal cancer. Oligopeptide nutrition could improve the nutritional status and immune function, and accelerate the restoration of intestinal function in colorectal cancer patients.