脂微球载体前列腺素E_1治疗慢性动脉闭塞症的临床评估

Lipo Prostaglandin E_1 in Treatment of Chronic Arterial Obstruction

目的 :观察脂微球载体前列腺素 E1(L ipo PGE1)对慢性动脉闭塞症的疗效及不良反应。方法 :用 L ipo PGE11 0μg静脉推注治疗慢性动脉闭塞 2 9例 ,用前列腺素 E1(PGE1)粉针剂 1 0 0μg静脉滴注治疗 2 0例作对照。结果 :L ipo PGE1组与 PGE1组综合疗效的有效率分别为 89.7%和 80 .0 %(P>0 .0 5 )。不良反应发生率分别为 3.4%与 45 .0 % (P<0 .0 0 5 )。结论 :L ipo PGE1治疗慢性动脉闭塞症用 PGE1粉针剂 1 /1 0的剂量即能达到同样的疗效 ,且不良反应显著下降 ,用药方法简便易行。

Objective:To evaluate the effect and side effect of Lipo PGE 1 in treatment of chronic arterial obstruction.Methods:10 μg Lipo PGE 1 was administated intravenously to 29 patients with chronic arterial obstruction,100 μg PGE 1 was given by iv gtt to patients with chronic arterial obstruction as control.Results:The effective rate was 89.7% and 80.0% in Lipe PGE 1 and PGE 1 group ( P >0.05).Side effect was 3.4% and 45.0% in Lipo PGE 1 and PGE 1 group respectively ( P <0.005).Conclusion:PGE 1 and 10% Lipo PGE 1 can reach the same effect to chronic arterial obstruction and side effect decreases significantly,which is more convenient.