环磷腺苷葡胺与磷酸肌酸钠治疗新生儿窒息后心肌损害的临床观察

Cinlical Observation of Meglumine Adenosine Cyclophosphate and Creatine Phosphate Sodium in the Treatment of Cardiac Damage Due to Neonatal Asphyxia

目的观察环磷腺苷葡胺与磷酸肌酸钠治疗新生儿窒息后心肌损害的治疗效果。方法将58例新生儿窒息后心肌损害的患儿随机分成磷酸肌酸钠（34例）与环磷腺苷葡胺组（24例）,两组病例均按照新生儿窒息作综合处理,磷酸肌酸钠组加用磷酸肌酸钠静脉滴注,剂量为0.5g/次,1次/d,环磷腺苷葡胺组加用环磷腺苷葡胺静脉滴注,剂量为3~5mg/（kg次）,1次/d,7d为1疗程。观察两组患儿治疗后症状、体征、肌酸激酶同工酶CK-MB和肌钙蛋白I（cTnI）的改变。结果环磷腺苷葡胺组与磷酸肌酸钠组在有效率、改善CK-MB和cTnI方面临床结果相近。结论磷酸肌酸钠和环磷腺苷葡胺作用于新生儿窒息后心肌损伤的不同环节,临床观察对改善心脏泵血功能、保护心肌细胞疗效相似,其预后相近,但环磷腺苷葡胺价格不及磷酸肌酸钠的1/5,能显著减轻患者负担,有临床推广价值。

Objective To observe the therapeutic effects between meglumine adenosine cyclopboshate and creatine phoshate curing myocardial injury of neonatal asphyxia.Method 58 myocardial injury cases of neonatal asphyxia were randomly divided into creatine phosphate sodium group（34 cases） and meglumine adenosine cyclopboshate group（24 cases）.Both of them had accepted comprehensive treatment.Phosphate muscle acid sodium group plus with phosphate muscle acid sodium vein drops note,dose for 0.5g/times,1 time/day,ring phosphorus glands glycoside portuguese amine group plus with ring phosphorus glands Glycoside Portuguese amine vein drops note,dose for each times 3-5mg/kg,1 time/day.One course of treatment is seven days.After the course of treatment,observing the changes of newborns,symptoms,signs,creatine kinase isozymes CK-Mb and troponin I（cTnI）.Results The results of the two groups are similar to each other.The clinical results of cTnI and CK-Mb is effectively improved in both groups.Conclusion Creatine phosphate sodium and meglumine adenosine cyclopboshate on myocardial injury after neonatal asphyxia in different aspects,clinical observation on improving cardiac pump function,the protection of myocardial cells of similar efficacy and prognosis are similar,but the price of meglumine adenosine cyclophosphate is one tenth of the price of creatine phosphate sodium,that can significantly reduce the cost,which has clinical promotional value.