低分子肝素联合硫酸镁治疗重度妊娠期高血压病的临床分析

Clinical Analysis of Low Molecular Weight Heparin Combined with Magnesium Sulfate Treatment of Severe Gestational Hypertension

目的探讨低分子肝素联合硫酸镁治疗重度妊娠期高血压病的疗效及其安全性。方法选取我院收治的重度妊娠期高血压病患者160例,随机分为两组。治疗组80例,采用低分子肝素联合硫酸镁治疗;对照组80例,采用硫酸镁治疗。检测两组产妇血浆D-二聚体水平、血小板计数及凝血酶原时间,测量产后或术后2h内出血量。结果治疗组D-二聚体水平较对照组明显降低(P<0.05),而血小板计数和凝血酶原时间无明显降低(P>0.05),两组产后或术后2h内出血量无显著性差异(P>0.05)。结论低分子肝素联合硫酸镁治疗重度妊娠期高血压病疗效确切,安全可靠,值得推广应用。

Objective To investigate the low molecular heparin combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension efficacy and safety.Methods 160 patients with severe pregnancy induced hypertension in our hospital were selected,randomly divided into two groups.The treatment group of 80 cases,the use of low molecular weight heparin combined with magnesium sulfate treatment;80 cases in the control group,treated with magnesium sulfate.Detection of two groups of maternal plasma D-two level of D-dimer,platelet count and prothrombin time,measuring postpartum or after 2 h internal bleeding.Results The treatment group two D-dimer levels were significantly lower than those of the control group（P0.05）,and the platelet count,prothrombin time without significantly decreased（P0.05）,two groups of postpartum or after 2h internal bleeding without significant difference（P0.05）.Conclusion Low molecular heparin combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension disease period is exact,safe and reliable,and is worthy of popularization and application.