摘要
硫酸软骨素(CS)是从动物(猪、牛、鸡、鲨鱼)软骨中提取的酸性粘多糖,是一种重要的药用生物大分子,目前已被广泛应用于关节炎治疗和滴眼液等领域。本文重点阐述了CS在治疗关节炎方面的疗效和机制,证实它可以较大程度上缓解关节炎患者的疼痛,改善关节功能,并且稳定关节间隙,尤其是在与葡萄糖胺(GS)联用后,效果更加明显。其治疗关节的作用机制主要包括以下三种:①提高细胞外基质(ECM)中蛋白多糖、CS和透明质酸等的合成;②抑制发炎因子(髓过氧物酶、N-乙酰氨基葡萄糖苷酶、胶原酶、透明质酸酶、弹性蛋白酶)等的合成;③抑制软骨的退化。本综述可加深人们对CS治疗骨关节炎的了解。
Chondroitin sulfate（CS） is a sulfated glycosaminoglycan（GAG） extracted from cartilage of pig,moggy,chicken and shark.As an important biomacromolecule,CS has become a widely used dietary supplement for treatment of osteoarthritis（OA） and a supplement of eyedrop for relaxing tired eyes.This paper reviewed the research progress of CS on osteoarthritis treatment,mainly focused on the curative effect and pharmacology.The results confirmed that the CS can do be used as a symptomatic slow-acting drug for this disease.For example,oral CS decreased pain,improved knee function and inhibited knee joint space narrowing.When the CS is used combining with Glucosamine（GS）,this effect is more evident.The effect of CS in curing the OA may be through three main mechanisms： ①stimulation of ECM（PG,CS,hyaluronate） production by chondrocytes;②suppression of inflammatory mediators;③ inhibition of cartilage degeneration.This review may be helpful in understanding the role of CS in OA treatment.
出处
《中国医药指南》
2013年第23期453-455,共3页
Guide of China Medicine
关键词
硫酸软骨素
关节炎
机制
研究进展
Chondroitin sulfate
Osteoarthritis
Mechanism
Research progress
