急性脑梗死患者颈动脉狭窄程度和血浆纤维蛋白原水平相关性研究

Study on the relationship between carotid artery stenosis and the level of fibrinogen in acute cerebral infarction

目的应用超声检查急性脑梗死患者颈动脉狭窄程度,探讨动脉硬化程度和血浆纤维蛋白原水平的相关性。方法选取217例急性脑梗死患者行颈动脉多普勒超声检查,将217例患者分成颈动脉狭窄组142例和无颈动脉狭窄组75例,同期住院的非脑血管病患者65例作为对照组,均于住院次日凌晨采血测定纤维蛋白原水平。结果伴颈动脉狭窄的急性脑梗死患者纤维蛋白原水平显著高于无颈动脉狭窄组,差异有统计学意义(P<0.05);纤维蛋白原水平与颈动脉狭窄严重程度成正相关(P<0.05)。结论颈动脉狭窄是急性脑梗死的重要危险因素;急性脑梗死患者血浆纤维蛋白原水平与颈动脉粥样硬化的程度密切相关,对急性脑梗死患者的治疗和预防再发提供依据。

Objective To study the relationship between carotid artery stenosis and the level of fibrinogen in acute cerebral infarction patients.Methods 217 cases of acute cerebral infarction patients were continously collected.Color Doppler ultrasonography of carotid artery were performed.All selected patients were divided into carotid artery stenosis group which contained 142 cases and non-carotid artery stenosis group which contained 75 cases.Control group contained 65 cases with non-cerebral infarction in the same period hospitalized patients.The level of fibrinogen was measured in morning hollow serum.Results The level of fibrinogen were significantly higher in carotid artery stenosis group than that in the non-carotid artery stenosis group（P 0.05）;The level of fibrinogen was related with the severity of carotid artery stenosis positively（P 0.05）.Conclusion Carotid artery stenosis is an important risk factor in acute cerebral infarction;The level of fibrinogen is an important risk factor in carotid atherosclerosis;and it is also important in predicting acute cerebral infarction in patients with carotid artery stenosis.