多囊卵巢综合征与高同型半胱氨酸血症相关性的研究进展

Advances of correlations between polycystic ovary syndrome and hyperhomocysteinemia

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一组以内分泌代谢紊乱为主的综合征,临床表现主要包括月经稀发、排卵障碍、高雄激素血症以及卵巢多囊样改变。PCOS患者发生2型糖尿病、动脉硬化以及心血管疾病的风险增加,这主要和PCOS患者体内各种因素导致的胰岛素代谢紊乱和血管内皮系统损伤有关。同型半胱氨酸(homocysteine,HCY)作为血管内皮损伤的标志之一,是心血管疾病发病的独立危险因素,PCOS患者往往伴有高同型半胱氨酸血症(hyperhomocysteinemia,HHCY),这可能是导致PCOS患者心血管并发症的重要因素之一。目前PCOS患者体内HCY水平升高的机制尚未完全清楚,现就国内外这方面的研究进展做一综述。

Polycystic ovary syndrome （PCOS） is a common endocrine disorder which involves oligomenorrhea, ovulatory problems, hyperandrogenism, and polycystic ovary. The women with PCOS may have some remote complications such as type 2 diabetes metlitus, atherosclerosis, and cardiovascular disease. All these complications may partly attribute to hyperinsulinemia, insulin resistance, and dysfunction of endothelial system. Homocysteine （HCY）, one of the most important marks reflecting endothelial dysfunction, is an independent risk factor of cardiovascular disease. And this may be an important cardiovascular disease risk factor for women with PCOS since these women are probably subjected to hyperhomocysteinemia （HHCY）. So far.it＇ s not well known why women with PCOS are subjected to HHCY. This paper reviews the progress in this aspect of research, and here giving some possible suggestions.