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牙源性角化囊性瘤开窗减压术前后Bcl-2及Ki-67的表达及意义 被引量：2

Expression of Bcl-2 and Ki-67 and their significance in keratocystic odontogenic tumor before and after decompression
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摘要 目的探讨牙源性角化囊性瘤(KCOT)开窗减压术前后Bcl-2、Ki-67的表达及开窗术治疗KCOT的可能机制。方法收集经病理证实的7例KCOT患者,分别于手术时及术后3个月、9个月切取病理标本,行Bcl-2及Ki-67免疫组化染色。资料进行统计学处理。结果 KCOT开窗术后Ki-67阳性表达细胞减少,增殖指数降低(P<0.05);Bcl-2阳性细胞较术前减少(P<0.05),术后9个月7例患者均呈阴性表达。结论开窗减压术后KCOT上皮增殖能力下降,可能是其治疗KCOT的部分机制。 Objective To investigate the expression of Ki-67 and Bcl-2 protein in epithelium of keratocystic odontogenic tumor （KCOT） before and after decompression. Methods The paraflqn-embeded tissue sections of KCOT befor and after decompression were used for immunohistochemical detection of Ki-67 and Bcl-2, and the results were statistically analyzed. Results Ki-67 expression in KCOT was down-regulated after decompression（ P 〈 0. 05 ）. The Bcl-2 expression in postoperative KCOT epithelium was significantly less than ,in preoperative KCOT epithelium （ P 〈 0. 05 ）. Conclusion The proliferation of KCOT epithelium after decompression decreased, which may be part of the mechanism of decompression therapy.
作者 刘艾姝 韩正学
机构地区 首都医科大学口腔医学院口腔颌面外科
出处 《北京口腔医学》 CAS 2013年第4期188-191,共4页 Beijing Journal of Stomatology
基金 北京市教委科研基金(KM201110025022)
关键词 牙源性角化囊性瘤 开窗减压术 BCL-2 KI-67 Keratocystic odontogenic tumor Decompression Ki-67 Bcl-2
分类号 R739.8 [医药卫生—肿瘤]
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参考文献13

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二级参考文献8

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北京口腔医学
2013年 第4期

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