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甲状旁腺激素及其受体与骨关节炎的关系研究进展 被引量：2

Research progress of the relationship among parathyroid hormone, parathyroid hormone-related receptors,and osteoarthritis
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摘要 骨关节炎是一种以关节软骨破坏、软骨下骨的硬化和滑膜反应为特征的慢性疾病。目前发现甲状旁腺激素(Parathyroid hormone,PTH)能够抑制骨关节炎患者软骨细胞终末期成熟分化,有明显软骨保护、延缓骨关节炎进展的作用。通过研究PTH、PTHR与骨关节炎的关系,对骨关节炎治疗及预后将起到重要的指导作用。 Osteoarthritis is a chronic disease characterized by articular cartilage degradation, subchondral bone sclerosis, and synovial reaction. Recent studies reveal that parathyroid hormone （PTH） can inhibit the maturation and differentiation of human osteoarthritis chondrocytes at the terminal stage, which can significantly protect cartilage and delay the progress of osteoarthritis. The research of the relationship among PTH, PTHR, and osteoarthritis may play an important guiding role in the treatment and prognosis of osteoarthritis.
作者 孙敏 尹良军
机构地区 重庆医科大学 重庆医科大学附属第二医院骨科
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2013年第8期885-888,875,共5页 Chinese Journal of Osteoporosis
关键词 骨性关节炎 甲状旁腺激素 甲状旁腺激素相关受体 软骨细胞 Osteoarthritis Parathyroid hormone Parathyroid hormone-related receptor, Chondrocyte
分类号 R684.3 [医药卫生—骨科学]
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参考文献22

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同被引文献20

  • 1黄江渝,胡汶竹.血清骨钙素水平检测的临床应用现状[J].现代预防医学,2007,34(9):1674-1675. 被引量：53
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  • 6Muir P, McCarthy J, Radtke CL, et al. Role of endochondral ossification of articular cartilage and functional adaptation of the subchondral plate in the development of fatigue microc- racking of joints[J]. Bone,2006,38(3) :342-349.
  • 7Holick MF. Resurrection of vitamin D deficiency and rickets [J]. J Clin Invest ,2006 ,116(8):2062-2072.
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  • 9Mistretta VI, Delanaye P, Chapelle JP, et al. Vitamin D2 or vitamin D3rJ]. Rev Med Interne , 2008 ,29(10):815-820.
  • 10Papasani MR, Gensure RC,Yan YL, et al. Identification and characterization of the zebrafish and lug" genes encoding tu- beroinfundibularo peptide 39[J]. Endocrinology, 2004, 145 (11) : 5294-5304.

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中国骨质疏松杂志
2013年 第8期

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