广西鸡屎藤的化学成分研究

Chemical constituents of Paederia pertomentosa

利用硅胶柱色谱、ODS柱色谱等色谱技术对广西鸡屎藤Paederia pertomentosa全草95%乙醇浸提物进行分离纯化,共得到5个化合物,根据理化数据和波谱数据鉴定化合物的结构分别为1,2-二甲氧基-3,4-二羟基蒽醌,命名为鸡屎藤蒽醌(1)、鸡屎藤苷(2)、去乙酰车叶草苷酸甲酯(3)、鸡屎藤酸(4)、鸡屎藤酸甲酯(5)。其中,化合物1为新化合物,并对大肠杆菌和金黄色葡萄球菌有明显抑制作用,化合物2～5均为首次从广西鸡屎藤中分离得到。

Five constituents were extracted from the aerial part of Paederia pertomentosa and isolated by column chromatogra- phy. Their structures were elucidated by physicochemical properties and spectroscopic data analysis. The isolated compounds were identified as 1,2-dimethoxy-3,4-dihydroxyanthraquinone named as paederone （1）, paederoside （2）, deacetyl asperulosidic acid meth- yl ester （3）, paederosidic acid （4） and methylpaederosidate （5）. Compound I is a new compound which exhibits a significant inhibi- tory effect on Escherichia coli and Staphylococcus aureus. Compounds 2-5 were isolated from this plant for the first time.