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干细胞及肿瘤细胞中nucleostemin基因的研究进展 被引量：2

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摘要 Nucleostemin(NS)基因在干细胞中高表达,在干细胞分化时迅速减少,参与干细胞和肿瘤细胞的增殖调控,维持干细胞扩增并抑制其向成熟细胞分化,从而阻止细胞凋亡。NS基因在肿瘤细胞干细胞特性维持中也起重要作用。NS蛋白以依赖于GTP的形式穿梭于核仁和核质之间,参与核糖体特别是前核糖体rRNA的装配过程。NS基因与肿瘤发生关系密切,或可作为靶向治疗的候选基因。
作者 韩崇旭 许文荣 孙艳
机构地区 苏北人民医院临床医学检测中心 江苏大学教务处 苏北人民医院生殖中心
出处 《临床检验杂志》 CAS CSCD 北大核心 2013年第7期514-517,共4页 Chinese Journal of Clinical Laboratory Science
基金 江苏省自然科学基金资助项目(BK2007072) 江苏省卫生厅"科教兴卫工程"医学重点学科"实验诊断学"开放性课题(XK200723/WKF0809)
关键词 NUCLEOSTEMIN基因 干细胞 肿瘤
分类号 R363.1 [医药卫生—病理学] Q291 [生物学—细胞生物学]
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参考文献27

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二级参考文献13

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临床检验杂志
2013年 第7期

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