摘要
目的探讨前列地尔对糖尿病肾病患者血清同型半胱氨酸（Hcy）和白细胞介素-18（IL-18）的影响。方法100例糖尿病肾病患者随机分为两组，观察组50例，对照组50例，对照组采用常规治疗，观察组在常规治疗的基础上加用前列地尔，两组共治疗4周。治疗前后测定患者的24h尿蛋白定量、血清Hey和IL-18。结果治疗后两组24h尿蛋白定量均明显减少（P〈0．01），两组比较差异有统计学意义（P〈0．05）。两组治疗后血清Hcy、IL-18均明显减少（P〈0．01），且两组比较差异有统计学意义（P〈0．05）。结论前列地尔可以明显缓解糖尿病肾病患者的病情，与保护血管、减少炎性反应有密切关系。
Objective To investigate the effectiveness of alprostadil on serum homocysteine （Hcy） and inreleukin-18 （IL-18） in patients with diabetic nephropathy. Methods One hundred pa- tients with diabetic nephropathy were randomly divided into two groups, the control group （n = 50 ） and the observation group （n = 50）. Patients in the control group were treated with the conventional treat- ment, and patients in the observation group were treated with the conventional treatment plus alprostadil. The 24-hours urinary protein, Hcy and IL-18 were detected before and after treatment. Results 24- hours urinary protein in both groups were decreased after treatment（ P 〈0.01 ）. There was a significant difference between the two groups （ P 〈 0.05 ）. Hcy and IL-18 in both groups were decreased after treat- ment（ P 〈0. 01 ）, and there was a significant difference between the two groups（ P 〈 0.05 ）. Con- clusions Alprostadil can significantly alleviate the condition of patients with diabetic nephropathy,and protect the blood vessels, reducing the inflammatory response.
出处
《中国实用医刊》
2013年第17期51-53,共3页
Chinese Journal of Practical Medicine
