维吾尔族和汉族人群非酒精性脂肪肝相关危险因素分析

The analysis of the risk factors for non-alcoholic fatty liver disease in Uyghur and Han ethnicities

目的探讨维吾尔族和汉族非酒精性脂肪肝(NAFLD)的危险因素,为NAFLD的预防和治疗提供科学依据。方法采用横断面研究方法对4318名维吾尔族和汉族健康体检人群进行问卷调查,同时对其体质指数、腰围、血压、血糖、血脂、血尿酸(SUA)等生化指标进行检测。采用多因素非条件logistic回归分析NAFLD的相关危险因素。结果维吾尔族和汉族人群NAFLD检出率分别为45.2%(716/1584)、36.1%(986/2734);高尿酸血症检出率分别为9.5%(150/716)、17.2%(470/2734);SUA水平分别为(288.98±90.46)、(326.49±98.43)μmol/L;上述指标差异均有统计学意义(P<0.01)。多因素非条件logistic回归分析显示,男性(OR=1.476,95%CI:1.149～1.898)、年龄(OR=1.036,95%CI:1.028～1.044)、维吾尔族(OR=1.337,95%CI:1.114～1.604)、肥胖(OR=5.682,95%CI:4.731～6.823)、高血压(OR=1.260,95%CI:1.036～1.531)、淋巴细胞计数升高(OR=1.404,95%CI:1.221～1.613)、血红蛋白浓度升高(OR=1.018,95%CI:1.010～1.026)、高尿酸血症(OR=3.059,95%CI:2.278～4.107)、高甘油三酯血症(OR=2.328,95%CI:1.946～2.786)、低高密度脂蛋白胆固醇(OR=1.401,95%CI:1.119～1.755)以及高血糖(OR=2.004,95%CI:1.496～2.685)是发生NAFLD的危险因素。结论维吾尔族人群发生NAFLD的危险较汉族高,SUA水平与NAFLD密切相关。

Objective To explore the risk factors of non-alcoholic fatty liver disease（NAFLD） in Han and Uygur ethnicities and to provide the base for prevention and treatment of NAFLD.Methods A cross-sectional study was performed in 1 584 Uyghur residents and 2 284 Han residents by the Questionnaire and physical examination,which include the body mass index（BMI）,abdominal circumference,blood pressure,blood glucose,blood lipid and serum uric acid levels.The multivariable logistic regression analysis was used to evaluate risk factors of NAFLD.Results The morbidities of NAFLD in Uyghur residents and Han residents were 45.2% and 36.1%,respectively.The morbidities of hyperuricemia in Uyghur residents and Han residents were 9.5% and 17.2%,respectively.The level of serum uric acid in Uyghur residents and Han residents were（288.98±90.46） and（326.49± 98.43） μmol/L,respectively.There were significant differences of above three indexes between Uyghur residents and Han residents（P0.01）.The results of multivariable logistic regression analysis indicated that the risk factors of NAFLD were male gender（OR=1.476,95%CI：1.149～1.898）,age（OR=1.036,95%CI：1.028～1.044）,the Uygur nationality（OR=1.337,95%CI：1.114～1.604）,obesity（OR=5.682,95%CI：4.731～6.823）,hypertension（OR=1.260,95%CI：1.036～1.531）,the enhanced counts of lymphocyte（OR =1.404,95% CI：1.221 ～1.613）,high hemoglobin concentration（OR =1.018,95% CI：1.010-1.026）,hyperuricemia（OR=3.059,95%CI：2.278～4.107）,hypertriglyceridemia（OR=2.328,95%CI：1.946～2.786）,low-HDL（OR= 1.401,95%CI：1.119～1.755）,elevated FPG（OR=2.004,95%CI：1.496～2.685）.Conclusion The risk of NAFLD in Uyghur residents is higher than that of Han residents,there is the close relationship between the level of serum uric acid and the prevalence of NAFLD.