曲安奈德联合庆大霉素局部注射治疗眼睑炎性肉芽肿的临床观察

Clinical Observation of Local Injection of Triamcinolone Acetonide Combined with Gentamicin in the Treatment of Eyelid Inflammatory Granuloma

目的:观察曲安奈德联合庆大霉素局部注射治疗眼睑炎性肉芽肿的临床疗效。方法:选取60例眼睑炎性肉芽肿患者,将其按照随机数字表法均分为两组,A组患者接受曲安奈德单独注射治疗,B组患者接受曲安奈德+庆大霉素联合注射治疗。分别于治疗2、3周后,对两组患者的临床疗效进行评价,并记录两组患者眼睑肉芽肿硬度、大小及注射总针数和不良反应发生情况。结果:治疗2周后,两组患者的肉芽肿硬度和肉芽肿面积均较治疗前显著下降(P<0.05),且B组患者比A组的下降程度更为显著(P<0.05);A组患者接受注射的总针数(93针)也显著多于B组(71针,P<0.05);且B组患者总有效率(100.00%)显著高于A组(97.14%),两组比较差异均具有统计学意义(P<0.05)。治疗3周后,两组患者的总有效率、肉芽肿硬度、肉芽肿面积等数据比较,差异无统计学意义(P>0.05),但A组总有效患者的注射针数(127针)显著多于B组(108针),两组比较差异有统计学意义(P<0.05)。两组患者治疗期间未见不良反应发生。结论:曲安奈德局部注射治疗对眼睑炎性肉芽肿具有较为理想的临床疗效,与广谱抗菌药物联合应用可加快患者的康复进程、提高治疗效果。

OBJECTIVE：To observe the clinical efficacy of local injection of triamcinolone acetonide combined with gentamicin in the treatment of eyelid inflammatory granuloma.METHODS：60 patients with eyelid inflammatory granuloma were collected and randomly divided into 2 groups.Group A received injection with triamcinolone acetonide alone,and group B received combined injection of triamcinolone acetonide and gentamicin.2 and 3 weeks later,the clinical efficacy of 2 groups were evaluated.The hardness and area of granuloma,the number of inuections and ADR were record.RESULTS：2 weeks later,the hardness and area of granuloma in 2 groups was significantly decreased than before,but the decline of group B was more obvious than group A;the total number of injections in group A（93）was more than in group B（71）.The total effective rate in group B was 100.00%,which was higher than in group A（97.14%）,there was statistical difference between 2 groups（P0.05）.3 weeks later,total effective rate,the hardness and area of granuloma in 2 groups had no statistical difference（P0.05）.Total number of injections（127）and cured patients in group A were significantly more than in group B（108）,there was statistical significance（P0.05）.There was no ADR in 2 groups.CONCLUSIONS：Local injection of triamcinolone acetonide in the treatment of eyelid inflammatory granuloma could receive an ideal clinical efficacy.It combined with broad-spectrum antibiotics could improve the therapeutic efficacy and speed up the recovery process.