神秘果叶对小鼠高尿酸血症模型影响观察

Study of Miracle Fruit Leaf Extract on Anti-Hyperuricemia in Mice

目的:探讨神秘果叶对高尿酸血症的影响,为临床用药提供依据。方法:采用黄嘌呤+乙胺丁醇造KM小鼠高尿酸血症模型,观察神秘果叶对血尿酸、血糖、胆固醇等水平的影响。结果:神秘果叶低、中、高剂量组均可降低黄嘌呤+乙胺丁醇致高尿酸血症模型小鼠的血尿酸(UA)水平,与模型组比较,差异显著(P<0.01)。结论:神秘果叶有一定的降尿酸作用。

Objective：To investigate the effects of Miracle fruit leaf extract on uric acid in mice with hyperuricemia. Methods：Mice models with hyperuricemia were induced with adenine and ethambutol as well as uric acid in blood were measured to observe the in- fluence of miracle fruit leaf extract on mice models with hyperuricemia. Results ： Miracle fruit leaf extract can significantly reduce u- ric acid in blood of mice with hyperuricemia. Conclusion ： Miracle fruit leaf can improve pathological changes of hyperuricema.