P-AKT在非小细胞肺癌中的表达及意义

Expressions and significance of P-AKT in non-small cell lung cancer

目的研究P-AKT在非小细胞肺癌(non-small cell lung carcinoma,NSCLC)中的表达及意义,探讨其与NSCLC临床病理特征的关系,为NSCLC的诊断和治疗提供临床指导。方法采用免疫组织化学Maxvision二步法检测P-AKT在66例NSCLC和10例正常肺组织中的表达情况,采用SPSS13.0统计软件进行数据处理。结果 P-AKT在NSCLC中的阳性率为75.8%(50/66),在正常组织中的阳性率为20.0%(2/10),两组比较具有统计学意义(P<0.05)。在非小细胞肺癌中,P-AKT的过高表达与淋巴结转移、远处转移及分化程度密切相关(P<0.05)。结论 P-AKT在NSCLC中的表达显著高于正常肺组织,且与临床病理特征有相关性,表明P-AKT可能在NSCLC的发生发展中发挥着促进作用,检测该因子有助于判断NSCLC的恶性度以及为NSCLC的治疗提供治疗靶点。

Objective： To study the expressions and significance of P-AKT in non-small cell lung cancer,and explore the relationship of its and clinical pathologic features of non-small cell lung cancer,and to provide the clinical guidance for the diagnosis and treatment of non-small cell lung cancer.Methods： Immunohistochemistry Maxvision two-step method was used to examine the expressions of P-AKT in 66 cases of non-small cell lung cancer and 10 cases of normal lung tissue.Data were processed by SPSS version 13.0.Results： The positive expression rate of P-AKT was 75.8%（50/66） in non-small cell lung cancer,and 20.0%（2/10） in normal lung tissue,and the difference is significant in the statistics（P0.05）.In the non-small cell lung cancer,the overexpression of P-AKT had significant correlation with the differentiation extent of cancer tissue,metastasis of lymph nodes and distance（P0.05）.Conclusion： The expression of P-AKT in the non-small cell lung cancer is higher than that in the normal lung tissue,and it has significant correlation with the clinical pathologic features,which shows that P-AKT may play a role in promoting in the occurrence and development of non-small cell lung cancer.The detection of this factor is helpful to judge the malignant degree of NSCLC and provide therapeutic targets for treatment of NSCLC.