吲哚-2,3-二酮抗菌作用研究

The research of isatin's antibacterial activity

目的研究吲哚-2,3-二酮的抗菌作用。方法进行吲哚-2,3-二酮的体内外抗菌实验及急性、慢性毒性实验。结果体外抗菌试验结果显示,吲哚-2,3-二酮最低抑菌浓度(MIC)在大肠杆菌及金黄色葡萄球菌均为750μg/ml,其最低杀菌浓度(MBC)在大肠杆菌及金黄色葡萄球菌均为3000μg/ml。体内抗菌试验结果显示,25 mg/kg吲哚-2,3-二酮可使大肠杆菌和金黄色葡萄球菌导致的小鼠死亡率降低40%。结论吲哚-2,3-二酮有抗菌作用。

Objective： To study the isatin＇s antibacterial activity.Methods： Isatin in vivo antibacterial experiments and acute and chronic toxicity experiments were done.Results： The in vitro antimicrobial tests showed that isatin＇s minimum inhibitory concentration（MIC） in Escherichia coli and Staphylococcus aureus was 750μg/ml,the minimum bactericidal concentration（MBC） in E.coli and Staphylococcus aureus was 3000μg/ml.Vivo antibacterial test results showed that 25mg/kg isatin could lead to 40% reduction in mortality caused by E.coli and Staphylococcus aureus in mice.Conclusion： Isatin has an antibacterial effect.