阿德福韦酯治疗乙肝致低血磷性骨软化症的现状分析

Current Situation Analysis on Hypophosphatemic Osteomalacia after Adefovir Dipivoxil Therapy for Hepatitis B

对国内外关于阿德福韦酯低剂量给药导致低血磷性骨软化症的报道进行回顾性分析。调查表明,慢性乙型肝炎患者长期服用低剂量阿德福韦酯(每日10mg)可引起低磷性骨软化症,临床症状表现为进行性肌无力、骨痛,严重者造成骨折。国产药品说明书中无致骨软化症的警示,且临床难以确诊,应引起关注。对于阿德福韦酯引起骨软化症的发生频率、影响因素仍有待进一步研究。

Current situation of hypophosphatemic osteomalacia after adefovir dipivoxil therapy for hepatitis B with low dosage home and abroad was retrospectively analyzed.Investigations revealed hypophosphatemic osteomalacia might occur in chronic hepatitis B patients with long-term use of adefovir dipivoxil at dosage of 10mg per day.The clinical features were slowly progressive distal muscle weakness,bone pain or even fracture.For it’s difficulty to accurately diagnose in clinic and there is no warnings in the domestic drug specifications,more attention should be paid to the adverse reaction.The frequency and influence factors should be further researched.