补肾健脾中药对围绝经期妇女骨代谢和雌激素的影响

Effect of Kidney_nourishing and Spleen_strengthening Herbal Medicine on Bone Metabolism and Serum Estradiol in Postmenopausal Women

目的 :研究补肾健脾中药对围绝经期妇女肾虚证与骨代谢、雌激素紊乱的防治效果和作用机制。方法 :将 96例围绝经期骨质疏松的肾虚证患者随机分为 3组 ,分别给予补肾健脾中成药 (膏剂 )和西药阿法D3治疗 ,并设安慰剂对照组 ,进行临床效果观察和治疗前后各组的骨面密度、血清雌激素水平检测。结果 :治疗 3个月后 ,中药组和西药组患者的骨面密度显著提高 ;两组总有效率相仿 ,但前者的显效率明显优于后者 ;两组的血清雌激素水平呈上升趋势。而安慰剂对照组患者的骨面密度及血清雌激素水平呈进行性下降。结论 :补肾健脾中药治疗效果优于西药对照组 ,说明该药是防治围绝经期 (包括绝经后 )妇女骨代谢、雌激素紊乱的高效。

To study the effect of kidney_nourishing and spleen_strengthening herbal medicine (Bushen Yigu Gao) on bone metabolism and serum estradiol in postmenopausal women with kidney deficiency syndrome, ninety_six cases of postmenopausal osteoporosis were randomly allocated to three groups: group A (placebo of soft extract and placebo of capsule), group B (Bushen Yigu Gao and placebo of capsule) and group C (α_D3 Capsule and placebo of soft extract). The score of ostealgia, bone mineral density(BMD) of radius and ulna and serum estradiol level were observed. The results showed that after a 3_month treatment course, BMD was increased in group B and group C; the total effective rate in group B was similar to group C but the remarkably effective rate was superior; serum estradiol level was both increased in the two groups. However, BMD and serum estradiol level were decreased in group A. It is indicated that kidney_nourishing and spleen_strengthening herbal medicine exerts a better effect in preventing and treating the disorders of bone metabolism and serum estradiol in postmenopausal women.