吸入呋塞米对急性发作期支气管哮喘患者肺通气功能的影响

Effect of inhaled furosemide on lung function in patients with acute exacerbation of asthma

目的 探讨吸入呋塞米对急性发作期支气管哮喘 (哮喘 )患者肺通气功能的影响。方法 将 6 0例轻、中度发作期哮喘患者随机分为 A、B、C三组 ,每组各 2 0例。A组吸入生理盐水 5 ml,B组吸入呋塞米 5 0 mg(5 ml,10 mg/ ml) ,C组吸入 0 .1%沙丁胺醇溶液 5 ml。观察三组患者吸药后15 min肺通气功能的变化。结果 吸药后 15 min B、C组用力肺活量 (FVC)、第 1s用力呼气容积(FEV1 )、最大呼气流量 (PEF)、5 0 %肺活量时最大呼气流量 (V5 0 )、2 5 %肺活量时最大呼气流量(V2 5 )等与其正常预计值的百分比 FVC%、FEV1 %、PEF%、V5 0 %、V2 5 %均显著高于其吸药前 ,且显著高于 A组吸药后。结论 吸入呋塞米可减轻气道阻塞 ,改善发作期哮喘患者肺通气功能。

Objective To investigate the effect of inhaled furosemide on lung function in patients with acute exacerbation of asthma.Methods 60 patients with acute mild or moderate exacerbation of asthma were randomly divided into A, B and C group, each group contained 20 cases. The patients in group A inhaled 5ml normal saline as placebo-control, group B inhaled furosemide 50mg (5 ml, 10 mg/ml), group C inhaled 0.l% salbutamol solution 5 ml. The percent of forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), peak expiratory flow (PEF), maximal expiratory flow at 50% vital capacity (V 50 ) and maximal expiratory flow at 25% vital capacity (V 25 ) to their normal predicted value as FVC%, FEV 1%, PEF%,V 50 % and V 25 % were measured before therapy and at 15 minutes after therapy. Results No significant difference was observed in the baseline lung function in the three groups. In group B and group C, FVC%, FEV 1%, PEF%, V 50 % and V 25 % all significantly increased in 15 minutes after inhalation, while in group A no significant change occured.Conclusion Furosemide given by inhalation can reduce the bronchoconstriction and ameliorate the lung function in patients with acute exacerbation of asthma. [