IFN-α对慢性乙型肝炎患者血清IL-2和SIL-2R水平的影响

Effect of IFN-αon serum IL-2 and SIL-2R in the patients with chronic hepatitis B

目的 探讨 IFN- α对慢性乙型肝炎 (乙肝 )患者血清 IL- 2、SIL- 2 R水平的影响。方法 分别采用放射免疫法 (RIA)和双抗体夹心 EL ISA法检测 30例慢性乙肝患者干扰素治疗前后血清IL- 2、SIL- 2 R水平 ,以 30例健康献血员作为对照。结果 慢性乙肝患者血清 IL- 2和 SIL- 2 R水平明显高于对照组 (P <0 .0 5 )。干扰素治疗后 ,应答者 43% ,非应答者 5 7%。应答者 IL- 2水平明显高于非应答者 (P <0 .0 1) ;而 SIL- 2 R水平在应答者低于治疗前 (P >0 .0 5 ) ,在非应答者明显高于治疗前 (P <0 .0 1)。结论 干扰素参与慢性乙肝细胞免疫调控。

Objective To study the effect of IFN-α on serum IL-2,SIL-2R in patients with chronic hepatitis B.Methods Serum IL-2 and SIL-2R were measured by RIA and ELISA respectively in 30 patients with chronic hepatitis B before and after treatment with IFN-α,being compared with 30 normal controls.Results The serum IL-2 and SIL-2R levels in patients were significantly higher than normal controls(P<0.05).After treatment with IFN-α,the IL-2 levels in responders were significantly higher than those in irresponders. The SIL-2R levels in responders decreased(P> 0.05 ) after treatment, being contrary to those in irresponders(P<0.01). [