无抽搐电休克治疗(MECT)合并药物与单纯药物治疗双相情感障碍躁狂相临床对照研究

Clinical Control Study on Drug or Drug Combined with MECT Therapy in Bipolar Disorder

目的:探讨应用无抽搐电休克治疗(MECT)合并药物与单纯药物治疗双相情感障碍抑郁相和躁狂相患者两种方法在起效时间、住院时间、住院费用等方面有无差异。方法:抑郁组66例患者和躁狂组62例患者随机分组,两组分别运用无抽搐电休克治疗合并药物治疗和单纯使用药物治疗,采用简明精神病评定量表(BPRS)、贝克抑郁自评量表(BDI)、贝克躁狂量表(BRMS)对患者疗效进行评定。结果:MECT合并药物治疗在治疗2周时评分与治疗前相比差异显著(P<0.05),而单纯药物治疗在2周时无显著差异;出院前评分与治疗前相比,两种治疗方法评分均差异显著(P<0.01),两种治疗方法在各组治疗时间、住院费用方面相比有显著性差异(P<0.01)。结论:MECT合并药物治疗双相情感障碍患者起效快、疗效好,明显减少了住院天数,节约了患者的住院费用。

Objective：To compare the differences in the initial action time,the effect hospital treatment days and the treatment expense on bipolar disorder between modified electroconvulsive therapy（MECT） ctmlined with medication and medication therapy.Methods：A total of 66 depressive patients and 62 mania patients treated with MECT combined with medication therapy and only medication therapy randomly divided into two groups,The initial action time,hospital treatment days and hospital expense were comared between two groups,review analysis was conducted.The effect was assessed according to the scores of the BPRS,BRMS and BDI.Results：The scores of BPRS,BRMS or BDI had dignificant diffences were found after 2 weeks of treatment by MECT with medication therapy（P0.05）,but the scores had no differences by medication therapy.Significant difference were found before leaving hospital by two treatment method（P0.01）.The significant difference were found in the average hospital days、the average treatment expense（P0.01）.Conclusion：MECT with medication therapy is effective fast,safe and economical method in treatment of bipolar disorder.