两种单位的干扰素不同途径给药治疗肛周尖锐湿疣70例临床观察

Observation of Efficacy of Interferon Used in Different Ways for Treatment of Condylomata Acuminata

目的:观察两种不同的方法治疗肛周尖锐湿疣的疗效。方法:将70例患者随机分为治疗组与对照组,治疗组35例采用手术切除疣体,α-2b干扰素300万单位加灭菌注射用水稀释后基底部封闭注射,α-2b干扰素100万单位臀部肌肉注射全身给药;对照组35例采用手术切除疣体,α-2b干扰素100万单位加灭菌注射用水稀释后基底部封闭注射;比较两种方法的治愈率和复发率。结果:35例治疗组中治愈34例,复发1例,治愈率97.1%,复发率2.9%;而35例对照组中治愈27例,治愈率为77.1%,复发8例,复发率为22.9%;经统计分析发现治疗组治愈率明显高于对照组,而复发率明显低于对照组,且差异具有统计学意义(P<0.05)。结论:干扰素局部加全身给药治疗肛周尖锐湿疣治愈率高、复发率低、操作简单方便,适用于基层医疗单位,值得临床推广应用。

Objective：To observe the two different methods in treating perianal condyloma acuminata.Methods：70 patients were randomly divided into treatment group and control group,35 cases in the treatment group use operation exciion warts,interferon alpha-2b 1000000 units with sterile water for injection diluted basal closed injection,100 million units of interferon alpha-2b intramuscular injection in systemic drug delivery;35 cases in control group by operation excision warts,α-2b interferon 100 million units with sterile water for injection diluted basal closed injection;a comparison of two methods of cure rate and recurrence rate.Results：Of the 35 cases in treatment group 34 cases were cured,1 cases recurred,the cure rate was 97.1%,recurrence rate of 2.9%;and in 35 cases in the control group 27 cases were cured,the cure rate was 77.1%,recurrence occurred in 8 cases,the recurrence rate was 22.9%;the statistical analysis found that the cure rate in treatment group was significantly higher than that in the control group,but significantly lower recurrence rate in the control group,and the difference was statistically significant（P0.05）.Conclusion：Local interferon plus systemic drug treatment for perianal condyloma high cure rate,low relapse rate,simple and convenient operation,is suitable for basic medical units,it is worthy of clinical application.