摘要
目的:观察两种抗生素轮换策略指导下ICU患者医院感染的病原菌及其耐药性变化特点。方法:根据抗生素轮换方案将2011-01-2011-12我院ICU收治的22例医院感染患者分为升阶梯治疗组和降阶梯治疗组,观察医院感染病原菌及其耐药性特点,并与我院全年流行病学数据进行比较。结果:两组检出致病菌耐药率及中敏率均显著高于全年流调水平,敏感率显著低于全年流调水平。结论:两种抗生素轮换策略均不能减少耐药菌的产生,但耐药菌的种属及耐药谱存在差异。
Objective:To observe the pathogen and changes of drug resistance of nosocomial infection in intensive care unit under the direction of two antibiotic rotation strategies.Method:Twenty-two patients of nosocomial infection in intensive care unit from January 2011to December 2011were divided into escalation therapy group and de-escalation therapy group according to the antibiotic rotation strategy.The pathogen of nosocomial infection and its drug resistance were observed and compared with the annual epidemiological data of our hospital.Result:The pathogen resistance rate and moderate sensitivity rates in two groups were higher than the annual level.The drug sensitive rate was lower than the annual level.Conclusion:The two antibiotics rotation strategy can significantly affect the generation of resistant strains and its spectrum,but cannot reduce the appearance of resistant bacteria.
出处
《临床急诊杂志》
CAS
2013年第5期217-219,共3页
Journal of Clinical Emergency
关键词
重症监护病房
医院感染
抗生素
耐药性
intensive care unit
nosocomial infection
antibiotic
resistance