ICU患者医院感染病原菌耐药性变化的临床观察

Drug resistance changes of nosocomial infection in intensive care unit

目的:观察两种抗生素轮换策略指导下ICU患者医院感染的病原菌及其耐药性变化特点。方法:根据抗生素轮换方案将2011-01-2011-12我院ICU收治的22例医院感染患者分为升阶梯治疗组和降阶梯治疗组,观察医院感染病原菌及其耐药性特点,并与我院全年流行病学数据进行比较。结果:两组检出致病菌耐药率及中敏率均显著高于全年流调水平,敏感率显著低于全年流调水平。结论:两种抗生素轮换策略均不能减少耐药菌的产生,但耐药菌的种属及耐药谱存在差异。

Objective：To observe the pathogen and changes of drug resistance of nosocomial infection in intensive care unit under the direction of two antibiotic rotation strategies.Method：Twenty-two patients of nosocomial infection in intensive care unit from January 2011to December 2011were divided into escalation therapy group and de-escalation therapy group according to the antibiotic rotation strategy.The pathogen of nosocomial infection and its drug resistance were observed and compared with the annual epidemiological data of our hospital.Result：The pathogen resistance rate and moderate sensitivity rates in two groups were higher than the annual level.The drug sensitive rate was lower than the annual level.Conclusion：The two antibiotics rotation strategy can significantly affect the generation of resistant strains and its spectrum,but cannot reduce the appearance of resistant bacteria.