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中性粒细胞CXCR1、CXCR2活化及其信号传导 被引量：6

Activation and signal transduction of CXCR1 and CXCR2 on neutrophils
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摘要 中性粒细胞属非特异性免疫细胞,其表面可表达CXCR1和CXCR2。IL-8是其共同配体,它们彼此结合激活后续级联信号传导,产生一系列生物学效应,在介导炎症反应、促进血管新生、维持中性粒细胞稳态等起重要作用。Reparixin是非竞争变构的CXCR1和CXCR2阻滞剂,可抑制中性粒细胞过度趋化、迁移介导的炎症反应。 Neutrophils are non-specific immunocytes and can express CXCR1/2 which can activate subsequent cascade signals and produce series of biological effects in inflammatory induction, angiogenesis promotion, and neutrophils homeostasis maintenance by combi- ning with each other＇s common ligands such as IL-$. Reparixin, a typical noncompetitive allosteric inhibitor of CXCR1/2, can play posi- tive inhibitory role in inflammatory response induced by excessive chemotaxis and migration of neutrophils.
作者 韩忠燕 王健
机构地区 安徽理工大学医学院病原学与免疫学教研室
出处 《中国微生态学杂志》 CAS CSCD 2013年第8期975-978,共4页 Chinese Journal of Microecology
基金 安徽省自然科学基金(090413138) 安徽省自然科学基金(1308085MH148) 安徽省教育厅自然基金重点项目(KJ2010A086)
关键词 中性粒细胞 CXCR1 CXCR2 信号传导 Neutrophils CXCR1 CXCR2 Signal transduction
分类号 R37 [医药卫生—病原生物学] Q93 [生物学—微生物学]
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参考文献12

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二级参考文献37

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中国微生态学杂志
2013年 第8期

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