血清单胺氧化酶与肝纤维化四项在肝硬化早期诊断中的临床价值

The clinical significance of serum monoamine oxidase combined with liver fibrosis four markers detec- tion in the early diagnosis of liver cirrhosis

【摘要】目的探讨血清单胺氧化酶（monoamineoxidase，MAO）活性与肝纤维化四项联合检测在肝硬化早期诊断中的临床价值。方法选择肝硬化患者89例作为患者组．健康体检者40例作为对照组。采用速率法和放射免疫法检测血清MAO活性和肝纤维化四项的水平。采用SPSS11．0统计软件对数据进行分析。结果患者组肝纤维化四项水平和MAO活性均显著升高，与对照组比较差异均有统计学意义（P均〈0．05），且MAO活性与肝纤维化四项水平均呈正相关关系，其中透明质酸（hya｜uronic，HA）与MAO的相关性最好（r=0．948，P〈0．05）。在肝纤维化四项结果正常的患者中均有MAO异常检出率，且胶原Ⅳ正常的结果中MAO异常检出率最高为（51．10％）。结论血清MAO活性和肝纤维化四项水平均可反映肝纤维化的严重程度，且具有良好的相关性，但MAO更具敏感性，且方法、操作简便易行，便于临床推广应用。

Objective To investigate the clinical significance of serum monoamine oxidase （MAO） combined with liver fibrosis four markers detection in the early diagnosis of liver cirrhosis. Methods 89 inpa- tients with liver cirrhosis were the patient group, and 40 health physical people were control group. MAO activ- ity was detected by rate method, and the levels of liver cirrhosis four markers were detected by radioimmunoas- say. All data were analyzed by SPSS 11.0 statistical software. Results MAO activity and levels of liver fibrosis four markers in patient group were all higher than that in control group, and the differences all had statistical significance （Pall〈 0.05）. The levels of liver fibrosis four markers were all had positive correlations with MAO activity, and the hyaluronic（HA） had the best correlation with MAO（r~= 0.948, P〈 0.05）. In normal levels of liver fibrosis four markers for patient group, there were also detected unnormal levels of MAO. And the highest unnormal detection rate of MAO （51.10%） was in normal level of collegen IV. Conclusion Serum MAO activ- ity and liver fibrosis four markers can reflect the severity of liver fibrosis and are both excellent correlated. MAO is more sensitive indicator for early diagnosis of liver cirrhosis than liver fibrosis four markers. It＇s simple, ap- plicable to automatic biochemical analyze and easy to be spreaded.