3种途径补铁治疗育龄期妇女缺铁性贫血的疗效观察

Observation on curative effect of iron deficiency in women of childbearing age anemia with iron supplementation by three methods

目的观察并比较右旋糖酐铁片、右旋糖酐铁注射液、蔗糖铁注射液治疗育龄期妇女缺铁性贫血(IDA)的疗效及不良反应。方法将96例育龄期妇女IDA患者按照不同补铁途径随机分成口服组、肌肉注射组(肌注组)、静脉组,分别补铁治疗6周,对3组患者治疗前后血红蛋白(Hb)、血清铁蛋白(SF)的变化及不良反应进行分析和比较。结果补铁治疗6周后口服组总有效率64.7%(22/34),肌注组总有效率70.0%(21/30),静脉组总有效率96.9%(31/32),差异均有统计学意义(P<0.05);3组患者Hb和SF在组间、不同时点以及组间和不同时点的交互作用差异均有统计学意义(均P<0.05),其中静脉组均高于肌注组和口服组(均P<0.05)。静脉组仅1例(3.1%)发生轻微不良反应,明显低于口服组(38.2%)和肌注组(26.7%)(P<0.05)。结论蔗糖铁注射液治疗育龄期妇女IDA安全有效。

Objective The study aimed to observe and compare the efficacy and adverse effects of iron dextran tablets,iron dextran injection and iron sucrose injection. Methods Ninety-six women of childbearing age with iron- deficiency anemia were randomly divided into three groups： oral route, intramuscular route and intravenous route, who received iron supplementations for six weeks, respectively. The changes of hemoglobin levels, serum ferritin（SF） levels, and the adverse effects of the three groups were compared and analyzed before and after treatment. Results After six weeks of iron supplementations, the total effective rates in oral route, intramuscular route and intravenous route were respectively 64.7%, 70.0% and 96.9%, significant difference existed between them （ P〈 0.05）. The levels of hemoglobin and SF in three groups, the different time points and the interaction of among groups and the different points showed significant differences （all P 〈0.05）. Furthermore, serum hemoglobin and SF in intravenous route were significantly higher than those in oral route and intramuscular route （all P 〈0.05）. Only one case （3.1 %） in intravenous route developed mild adverse effects, which were significantly lower than those in oral route （38.2 % ） and intramuscular route （26.7 %）（ P 〈0.05）. Conclusion Iron sucrose injection in treating women of childbearing age with iron deficiency anemia is safe and effective.