重复洗胃对有机磷农药中毒病人血胆碱脂酶活性的影响

Effect of Repeated Gastrolavage on the Blood Cholinesterase Activity in Organophosphorus Pesticide Poisoning

为了探讨口服有机磷农药中毒后保留胃管重复洗胃对血胆碱酯酶活性的影响。将 180例口服有机磷农药中毒病人随机分为观察组和对照组 ,观察组 96例 ,保留胃管重复洗胃 ;对照组 84例 ,按常规法洗胃。观察两组每2 4h血胆碱酯酶活性变化。结果 :轻度中毒时 ,两组血胆碱酯酶活性比较 ,差异无显著性 (P>0 .0 5 ) ;中、重度中毒时 ,观察组血胆碱酯酶活性下降幅度小、回升快 ,与对照组比较 ,差异有极显著性 (P<0 .0 1)。提示保留胃管重复洗胃可将体内残留农药排出体外 ,血胆碱酯酶在无残毒继续抑制的情况下可迅速恢复活性。

The effect of repeated gastrolavage with retained gastric canal on blood cholinesterase activity in organophosphorus poisoning via gastrointestine was studied. 180 cases of poisoning due to oral organophosphorus pesticide were randomly divided into observation group ( n =96, receiving repeated gastrolavage) and control group ( n =84, receiving routine gastrolavage). The changes in blood cholinesterase activity in an interval of 24 h in the two groups were observed. The results showed that in mild poisoning, there was no significant difference in blood cholinesterase activity between the two groups ( P >0.05). However, in moderate or severe poisoning, blood cholinesterase activity in the observation group had a less decrease and returned to normal more quickly as compared with control group ( P <0.01). It was suggested that repeated gastrolavage through retained gastric canal could eliminate the residual pesticide from the body. The blood cholinesterase could be activated rapidly.