摘要
目的:对酮洛芬醇质体(KPFE)凝胶的毒理进行研究,以评价其生物安全性。方法:以豚鼠为实验动物,分别观察其完整皮肤及破损皮肤短时间接触KPFE凝胶后所产生的毒性反应,完整皮肤及破损皮肤单次与多次接触KPFE凝胶后的局部制激反应,并观察皮肤多次接触KPFE凝胶后机体免疫系统在皮肤上的反应结果:KPFE凝胶在豚鼠完整或破损皮肤局部均无明显刺激性及毒性反应,多次使用后,未见明显的其他毒性反应。结论:KPFE凝胶具有较高的皮肤应用安全性。
Objective ： To study the toxicology of ketoprofen ethosomal （KPFE） gels to evaluate the bio-safety. Method ： Guinea- pigs as the test animals, the toxicity in the complete and damaged skin treated by KPFE gels in a short time was observed, and the lo- cal irritation in the complete and damaged skin treated by KPFE gels with single or multiple dosage was studied. The general toxicity was also investigated after treated by KPFE gels for many times. Result： None of the tests showed the significant toxicity, local irritation or general toxicity. Conclusion： KPFE gels with promising skin application safety is valuable to be studied further.
出处
《中国药师》
CAS
2013年第8期1114-1116,共3页
China Pharmacist
