九味镇心颗粒联合脑电生物反馈疗法治疗广泛性焦虑障碍的对照研究

Comparative Study on Jiuwei Zhenxin Granules Combined with EEG Biofeedback Therapy in the Treatment of Generalized Anxiety Disorder

目的:比较九味镇心颗粒联合脑电生物反馈疗法与单一的脑电生物反馈疗法治疗广泛性焦虑障碍(GAD)的临床疗效。方法:78例GAD患者随机分为两组,研究组40例予九味镇心颗粒6 g,po,tid,同时联合脑电生物反馈疗法治疗;对照组38例予单一的脑电生物反馈疗法治疗。疗程均为6周。采用汉密尔顿焦虑(HAMA)、焦虑自评量表(SAS)、临床总体印象-疗效总评量表(CGI-GI)、药物不良反应量表(TESS)评定治疗效果结果:研究组总有效率为90.0%,对照组总有效率为68.4%,两组疗效差异有统计学意义(P<0.01);研究组在治疗的2,4,6周末,HAMA减分率均高于对照组(P<0.01)。结论:九味镇心颗粒联合脑电生物反馈疗法治疗广泛性焦虑障碍较单一的脑电生物反馈疗法具有更好的疗效,起效较对照组快,不良反应轻微,易耐受。

Objective： To compare the clinical efficacy of Jiuwei Zhenxin granules combined with EEG biofeedback therapy and that of EEG biofeedback therapy alone in the treatment of generalized anxiety disorder （GAD）. Method： Totally 78 patients （ CCMD- 3） were randomly divided into the study group and the control group. The study group （40 cases） was given Jiuwei Zhenxin granules combined with EEG biofeedback therapy. The control group （38 cases） was given EEG biofeedback therapy alone. The treatment dura- tion was six weeks. Hamihon anxiety scale（ HAMA）, self-rating anxiety scale（ SAS）, clinical global impression（CGI-GI） and treat- ment emergent symptom scale（TESS） were adopted to evaluate the clinical efficacy. Result： The effective rate was 90% in the study group and that in the control group was 68.4%. There was statistical significance between the two groups（P 〈 0.01 ）. The reducing rate of HAMA in the study group was higher than that in the control group （ P 〈 0.01 ） at the 2nd, 4th and 6th weekend during the treatment. Conclusion： Jiuwei Zhenxin granules s combined with EEG biofeedback therapy is better than EEG biofeedback therapy a- lone in the treatment of generalized anxiety disorder.